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Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 5, doi: 10.1007/s11783-021-1393-7
• The long-period groundwater evolution was identified by hydrochemicalsignatures.
Keywords: Groundwater quality Hydrochemical signatures Spatial-temporal variations Water-rock interactions
Detection of genomic signatures for pig hairlessness using high-density SNP data
Ying SU,Yi LONG,Xinjun LIAO,Huashui AI,Zhiyan ZHANG,Bin YANG,Shijun XIAO,Jianhong TANG,Wenshui XIN,Lusheng HUANG,Jun REN,Nengshui DING
Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 4, Pages 307-313 doi: 10.15302/J-FASE-2014039
Keywords: hairlessness pig selective sweeping
Fengle Zhu, Zhenzhu Su, Alireza Sanaeifar, Anand Babu Perumal, Mostafa Gouda, Ruiqing Zhou, Xiaoli Li, Yong He
Engineering 2023, Volume 22, Issue 3, Pages 171-184 doi: 10.1016/j.eng.2022.10.006
Keywords: Hyperspectral imaging Fingerprint spectral signatures Spot blotch Leaf lesion progression Presymptomatic
Fei LI, Wei GAO, Gui-lin WANG, Ke-fei CHEN, Chun-ming TANG
Frontiers of Information Technology & Electronic Engineering 2019, Volume 20, Issue 2, Pages 176-186 doi: 10.1631/FITEE.1700005
Keywords: Double-authentication-preventing signatures Chameleon hash function Digital signature Provable security
Verifier-local revocation group signatures with backward unlinkability from lattices Research Articles
Yanhua ZHANG, Ximeng LIU, Yupu HU, Yong GAN, Huiwen JIA
Frontiers of Information Technology & Electronic Engineering 2022, Volume 23, Issue 6, Pages 876-892 doi: 10.1631/FITEE.2000507
Keywords: Group signature Lattice-based cryptography Verifier-local revocation Backward unlikability Short integer solution
Tong Wu, Ying-Cheng Yang, Bo Zheng, Xue-Bing Shi, Wei Li, Wen-Cong Ma, Shan Wang, Zhi-Xuan Li, Yan-Jing Zhu, Jian-Min Wu, Kai-Ting Wang, Yan Zhao, Rui Wu, Cheng-Jun Sui, Si-Yun Shen, Xuan Wu, Lei Chen, Zhen-Gang Yuan, Hong-Yang Wang
Engineering 2021, Volume 7, Issue 10, Pages 1381-1393 doi: 10.1016/j.eng.2021.01.014
Intrahepatic cholangiocarcinoma (ICC) is the second most common liver cancer. Chemotherapy remains the main therapeutic strategy for advanced ICC patients, but chemosensitivity varies individually. Here, we applied cytometry by time-of-flight (CyTOF) to establish the immune profile of peripheral blood mononuclear cells (PBMCs) on the single-cell level at indicated time points before, during, and after chemotherapy. Multiplex immunofluorescence staining was applied to examine the spatial distribution of certain immune clusters. Tissue microarrays (TMAs) were used for prognostic evaluation. A total of 20 ICC patients treated with gemcitabine (GEM) were enrolled in our study, including eight cases with good response (R) and 12 cases with non-response (NR). Tremendous changes in PBMC composition, including an increased level of CD4/CD8 double-positive T cells (DPT), were observed after chemotherapy. Patients with higher level of CD4+CD45RO+CXCR3+ T cells before treatment had a favorable response to chemotherapy. Our study identified a positive correlation between the percentage of T cell subpopulations and clinical response after chemotherapy, which suggests that it is practical to predict the potential response before treatment by evaluating the proportions of the cell population in PBMCs.
Keywords: Intrahepatic cholangiocarcinoma Gemcitabine Chemosensitivity Peripheral blood mononuclear cells
Novel Genetic Risk and Metabolic Signatures of Insulin Signaling and Androgenesis in the Anovulation Article
Xiaoke Wu, Chi Chiu Wang, Yijuan Cao, Jian Li, Zhiqiang Li, Hongli Ma, Jingshu Gao, Hui Chang, Duojia Zhang, Jing Cong, Yu Wang, Qi Wu, Xiaoxiao Han, Pui Wah Jacqueline Chung, Yiran Li, Xu Zheng, Lingxi Chen, Lin Zeng, Astrid Borchert, Hartmut Kuhn, Zi-Jiang Chen, Ernest Hung Yu Ng, Elisabet Stener-Victorin, Heping Zhang, Richard S. Legro, Ben Willem J. Mol, Yongyong Shi
Engineering 2023, Volume 23, Issue 4, Pages 103-111 doi: 10.1016/j.eng.2022.08.013
Ovulation induction is a first-line medical treatment for infertility in polycystic ovary syndrome (PCOS). Poor ovulation responses are assumed to be due to insulin resistance and hyperandrogenism. In a prospective cohort (PCOSAct) of 1000 infertile patients with PCOS, whole-exome plus targeted singlenucleotide polymorphism (SNP) sequencing and comprehensive metabolomic profiling were conducted. Significant genome-wide common variants and rare mutations associated with anovulation were identified, and a prediction model was built using machine learning. Common variants in zinc-finger protein 438 gene (ZNF438) indexed by rs2994652 (p = 2.47 × 10–8) and a rare functional mutation in REC114 (rs182542888, p = 5.79 × 10–6) were significantly associated with failure of ovulation induction. Women carrying the A allele of rs2994652 and REC114 p.Val101Leu (rs182542888) had lower ovulation (odds ratio (OR) = 1.96, 95% confidence interval (95%CI) = 1.55–2.49; OR = 11.52, 95%CI = 3.08–43.05, respectively) and prolonged time to ovulation (mean = 56.7 versus (vs) 49.0 days, p < 0.001; 78.1 vs 68.6 days, p = 0.014, respectively). L-phenylalanine was found to be increased and correlated with the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index (r = 0.22, p = 0.050) and fasting glucose (r = 0.33, p = 0.003) for rs2994652, while arachidonic acid metabolism was found to be decreased and associated with increased anti-Müllerian hormone (AMH; r = –0.51, p = 0.01) and total testosterone (TT; r = –0.71, p = 0.02) for rs182542888. A combined model of genetic variants, metabolites, and clinical features increased the prediction of ovulation (area under the curve (AUC) = 76.7%). Common variants in ZNF438 and rare functional mutations in REC114, associated with phenylalanine and arachidonic acid metabolites, contributed to the failure of infertility treatment in women with PCOS.
Keywords: Polycystic ovary syndrome Infertility Ovulation responses ZNF438 REC114 Whole-exome sequencing Deep machine learning
Title Author Date Type Operation
Using hydrochemical signatures to characterize the long-period evolution of groundwater information in
Journal Article
Detection of genomic signatures for pig hairlessness using high-density SNP data
Ying SU,Yi LONG,Xinjun LIAO,Huashui AI,Zhiyan ZHANG,Bin YANG,Shijun XIAO,Jianhong TANG,Wenshui XIN,Lusheng HUANG,Jun REN,Nengshui DING
Journal Article
Fingerprint Spectral Signatures Revealing the Spatiotemporal Dynamics of Bipolaris Spot Blotch Progression
Fengle Zhu, Zhenzhu Su, Alireza Sanaeifar, Anand Babu Perumal, Mostafa Gouda, Ruiqing Zhou, Xiaoli Li, Yong He
Journal Article
Double-authentication-preventing signatures revisited: new definition and construction from chameleon
Fei LI, Wei GAO, Gui-lin WANG, Ke-fei CHEN, Chun-ming TANG
Journal Article
Verifier-local revocation group signatures with backward unlinkability from lattices
Yanhua ZHANG, Ximeng LIU, Yupu HU, Yong GAN, Huiwen JIA
Journal Article
Distinct Immune Signatures in Peripheral Blood Predict Chemosensitivity in Intrahepatic Cholangiocarcinoma
Tong Wu, Ying-Cheng Yang, Bo Zheng, Xue-Bing Shi, Wei Li, Wen-Cong Ma, Shan Wang, Zhi-Xuan Li, Yan-Jing Zhu, Jian-Min Wu, Kai-Ting Wang, Yan Zhao, Rui Wu, Cheng-Jun Sui, Si-Yun Shen, Xuan Wu, Lei Chen, Zhen-Gang Yuan, Hong-Yang Wang
Journal Article
Novel Genetic Risk and Metabolic Signatures of Insulin Signaling and Androgenesis in the Anovulation
Xiaoke Wu, Chi Chiu Wang, Yijuan Cao, Jian Li, Zhiqiang Li, Hongli Ma, Jingshu Gao, Hui Chang, Duojia Zhang, Jing Cong, Yu Wang, Qi Wu, Xiaoxiao Han, Pui Wah Jacqueline Chung, Yiran Li, Xu Zheng, Lingxi Chen, Lin Zeng, Astrid Borchert, Hartmut Kuhn, Zi-Jiang Chen, Ernest Hung Yu Ng, Elisabet Stener-Victorin, Heping Zhang, Richard S. Legro, Ben Willem J. Mol, Yongyong Shi
Journal Article